Tizanidine is one of many medications that shouldn t be stopped abruptly because it can cause withdrawal symptoms. Tizanidine withdrawal symptoms include high blood pressure, a fast heartbeat, and stiff muscles. Withdrawal symptoms are more likely if you ve been taking high doses of tizanidine (20 mg or more daily) for about 2 months or more.
Tizanidine, a short-acting muscle relaxant, acts on central alpha-2-adrenergic receptors to reduce spasticity. However, abrupt withdrawal of tizanidine can lead to symptoms such as hypertension, reflex tachycardia, hypertonicity, and anxiety as a result of high adrenergic activity. Few cases have been reported on tizanidine withdrawal syndrome.
The tizanidine treatment decreased the intensity of the withdrawal symptoms in every symptom type examined, and in the short course of the following (mean 9
The case report highlights the importance of recognizing tizanidine withdrawal symptoms. In addition, the importance of close monitoring, hemodynamic control, and reintroduction of tizanidine drug at a lower dose followed by tapering down for managing tizanidine withdrawal is emphasized.
Doing so may cause withdrawal symptoms. This is especially likely if you've been taking either drug for a long time. Withdrawal symptoms of tizanidine include:.
Tizanidine is one of many medications that shouldn t be stopped abruptly because it can cause withdrawal symptoms. Tizanidine withdrawal symptoms include high blood pressure, a fast heartbeat, and stiff muscles. Withdrawal symptoms are more likely if you ve been taking high doses of tizanidine (20 mg or more daily) for about 2 months or more.
Tizanidine is one of many medications that shouldn t be stopped abruptly because it can cause withdrawal symptoms. Tizanidine withdrawal symptoms include high blood pressure, a fast heartbeat, and stiff muscles. Withdrawal symptoms are more likely if you ve been taking high doses of tizanidine (20 mg or more daily) for about 2 months or more.
Tizanidine is closely related to clonidine, which is often abused in combination with narcotics and is known to cause symptoms of rebound upon abrupt withdrawal. Three cases of rebound symptoms on sudden withdrawal of tizanidine have been reported. The case reports suggest that these patients were also misusing narcotics.
CASE REPORTS DEPICTING TIZANIDINE WITHDRAWAL Author Year Case Strategy implemented Outcome of the case Morgom et al. [3] 2024 Tizanidine withdrawal Tizanidine taper Symptoms improved after initiating tizanidine taper Suelt et al. [4] 2024 Tizanidine withdrawal Tizanidine taper Symptoms improved after initiating tizanidine taper, blood
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