Pharmacokinetic research indicates that enzymes implicated in fluoxetine metabolism exhibit similar affinities for fluoxetine enantiomers (R-fluoxetine and S-fluoxetine); the only exception to this is the CYP2C9 enzyme which stereo-selectively metabolizes R-fluoxetine over S-fluoxetine.
Sertraline and citalopram show linear pharmacokinetics while fluoxetine, fluvoxamine, and paroxetine show nonlinear pharmacokinetics . The SSRIs are metabolized by the cytochrome P450 system in the liver.
20 mg once daily. Pharmacokinetics for fluoxetine. Consider the long half-life of fluoxetine when adjusting dosage (or in overdosage)
by AC Altamura 2024 Cited by 388In contrast with its effect on the pharmacokinetics of other antidepressants, age does not affect fluoxetine pharmacokinetics. This finding together with
Objectives: The aim of the present study was to evaluate the influence of Fluoxetine (antidepressant drug) on pharmacokinetic and
Pharmacokinetics: Fluoxetine has a long half-life: - fluoxetine 2-3 days. - Nor-fluoxetine 7-9 days. Changes in dosage would therefore not be
Fluoxetine (Prozac), Fluvoxamine (Luvox), and Paroxetine (Paxil). It highlights their pharmacokinetic and pharmacodynamic properties
does not affect fluoxetine pharmacokinetics. This finding together with the better tolerability profile of fluoxetine (compared with tricyclic
Pharmacokinetics for fluoxetine. Consider the long half-life of fluoxetine when adjusting dosage (or in overdosage). Unlicensed use.
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