Routine addition of anaerobic coverage for suspected aspiration pneumonia is not recommended unless Meropenem 1 g IV q8h (step down to cipro if
Clindamycin can be useful for lung abscess, due to combined coverage of anaerobes and oral streptococcal spp. Carbapenem ( Meropenem; imipenem/
Usually unnecessary to offer empiric double-coverage for anaerobic Bacteroides (e.g, metronidazole carbapenem [such as ertapenem or meropenem])
Double anaerobic coverage is the combination of 2 or more of the following agents: Carbapenems (Doripenem, Ertapenem, Imipenem, Meropenem) Cefotetan Cefoxitin
Meropenem (Merrem IV), 1 g IV every 8 hours Adding anaerobic coverage for CAP is not recommended unless lung abscess or empyema is suspected. CORTICOSTEROID AND ANTIVIRAL THERAPY.
Meropenem is active against many bacteria which are resistant to other antibiotics. Meropenem For anaerobic bacteria, the susceptibility to meropenem as MICs
Ciprofloxacin 400 mg IV. Q12H. /- Metronidazole. 500 mg IV Q8H. Meropenem 1gm Q8H. Piperacillin/tazobactam provides excellent anaerobic coverage, addition of
Indications and dose For meropenem Aerobic and anaerobic Gram-positive and Gram-negative infections, Hospital-acquired septicaemia for meropenem By intravenous infusion, or by intravenous injection
For the very resistant P. aeruginosa, doripenem and meropenem are highly potent because they require multiple drug resistance pathways. Imipenem is slightly less potent for P. aeruginosa, and ertapenem should not be used for P. aeruginosa because of poor activity. Anaerobic Coverage 1,2. All carbapenems have fairly good coverage against anaerobes.
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