history of bradycardia; (iv) recurrent unexplained syncope; (v) susceptibility to peptic inhibitors: donepezil (Aricept, Aricept ODT); rivastigmine (Exelon
Acebutolol. Both Donepezil and Acebutolol can increase the risk of bradycardia. Alectinib. Both Donepezil and Alectinib can increase the risk of bradycardia.
Symptomatic bradycardia with excessive doses of donepezil was reported in a 79 year-old patient with AD mistakenly administered a 50 mg dose. There are several case studies describing sinus bradycardia and AV block with therapeutic doses of donepezil[7, 8]
Donepezil is associated with rare incidences of heart block and sinus bradycardia. 1,14 Check heart rate before initiation; if it is under 60 per minute, an
bradycardia). In the second study, the mortality rates were 4/208 (1.9%) on donepezil hydrochloride 5 mg, 3/215 (1.4%) on donepezil
between donepezil and placebo (MD 2.60; 95% CI: [− 2.67, 7.78]). There was bradycardia, drug-drug interactions, and depression. These adverse.
by YJ Hong 2024 Cited by 23Interestingly, cardiologic symptoms such as bradycardia and syncope as side effects of high-dose donepezil were not reported in any of the
BRADYCARDIA: Donepezil can cause bradycardia (slow heartbeat), which can lead to fainting. Taking the medicine before bedtime can help
Beta-blockers, when taken alongside donepezil, may increase the risk of bradycardia. Medications that induce CYP2D6 and CYP3A4 enzymes, such as phenytoin
Comments
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