Lamotrigine during pregnancy

Physiological changes during pregnancy can affect the absorption Are doses of lamotrigine or levetiracetam adjusted during pregnancy?

pregnancy; however, women with epilepsy may require or be unintentionally exposed to lamotrigine during pregnancy. This Registry is

What else should I know about taking lamotrigine during pregnancy? Lamotrigine is cleared from the body faster during pregnancy. This means that many people who are pregnant need to increase their dose of lamotrigine to keep the medication at the right level to work for them.

Of the new anti-seizure medications, lamotrigine and levetiracetam are the most widely used due to their known safety during pregnancy. Clearance of lamotrigine and levetiracetam doubles during pregnancy compared to before pregnancy. Lamotrigine levels tend to dramatically decrease during pregnancy, increasing the risk of seizures.

Clearance of lamotrigine and levetiracetam doubles during pregnancy compared to before pregnancy. Lamotrigine levels tend to dramatically decrease during pregnancy, increasing the risk of seizures. One study showed an increased seizure risk for women on lamotrigine when blood levels fell below two-thirds of the medication levels prior to pregnancy.

lamotrigine levels before conception and monthly during pregnancy in 14 women. The best-fit curve of lamotrigine clearance ascended during the first 10 weeks of pregnancy and reached peak clearance at 32 weeks. Decreases in lamotrigine serum concentration across pregnancy in-crease the risk for symptom recurrence. Postpartum Pharmacokinetics

They also review the epilepsy literature on use of lamotrigine during pregnancy. Method: Lamotrigine serum samples were obtained from eight mother-infant pairs at different time points during pregnancy and the postpartum period. Results: All of the women were taking lamotrigine throughout pregnancy. Serum-level-to-dose ratios were lower during

Lamotrigine belongs to a class For more information about taking lamotrigine during pregnancy, see the Lamotrigine and pregnancy section

by R Lancaster . These changes in lamotrigine clearance during pregnancy indicate the need for at least monthly therapeutic monitoring during the pregnancy, and weekly