Plavix) to Alert Healthcare Professionals about a Drug Interaction with Omeprazole (Marketed as Prilosec FDA Reminder to Avoid Concomitant Use of Plavix (
The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole [Prilosec] or esomeprazole [Nexium]. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix. Plavix Prescribing Information
Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix. Avoid using omeprazole concomitantly or 12 hours apart with Plavix. Consider using another acid-reducing agent with less CYP2C19 inhibitory activity Plavix Prescribing Information. If possible, it is recommended to avoid taking Plavix and omeprazole together.
Omeprazole can reduce the effectiveness of Plavix, an antiplatelet drug, and increase the risk of cardiovascular events. Learn how omeprazole inhibits the liver enzyme that transforms Plavix and what alternatives to consider.
(Plavix) and its use when As such, the FDA recommends. against the concomitant use of Plavix (clopidogrel) and omeprazole because the co-administration.
Plavix (clopidogrel) patients should be Leading cardiologists challenge clinical importance of interaction between clopidogrel (Plavix) and omeprazole
Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (
Plavix (clopidogrel) patients should be Leading cardiologists challenge clinical importance of interaction between clopidogrel (Plavix) and omeprazole
(Plavix) and its use when As such, the FDA recommends. against the concomitant use of Plavix (clopidogrel) and omeprazole because the co-administration.
Hence Omeprazole being a much more expensive drug than it is now.....