Vigorex Vigorex citrate (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08%. Vigorex Vigorex (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Vigorex side effects
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When a single 100 mg dose of Vigorex was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in Vigorex systemic exposure (AUC).
Indications Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Vigorex to be effective, sexual stimulation is required. Vigorex is also indicated in pulmonary arterial hypertension. Description Vigorex is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP
In a study of healthy male volunteers, co-administration of Vigorex at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of cytochrome P450 2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of Vigorex AUC and a 55% decrease in Vigorex Cmax.
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