The published fluconazole PBPK model was integrated with the S-warfarin model to evaluate the inhibitory effect of fluconazole on S-warfarin metabolism. 43 Inhibition of CYP2C9 and CYP3A4 by fluconazole was established using a noncompetitive inhibition process.
by EV Hersh Cited by 2avoidance of fluconazole is recommended in patients taking warfarin fluconazole and metronidazole can inhibit warfarin's metabolism and lead to
Treatment. APO-FLUCONAZOLE (fluconazole) is indicated for the treatment of: receiving fluconazole concurrently with warfarin. Dose adjustments
Amiodarone. Increase. Decreases warfarin metabolism ; Antifungal agents. Increase. Fluconazole, ketoconazole, and miconazole (vaginal) decrease warfarin
Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin dose reduction for extended course. ; Fluoroquinolones, ↑. Not always clinically
Perioperative management of warfarin is covered in the BC Guideline Warfarin Therapy – Management During Invasive o fluconazole o itraconazole.
Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin dose reduction for extended course. ; Fluoroquinolones, ↑. Not always clinically
A common antifungal medication, fluconazole (Diflucan), can interact with many medications, like atorvastatin and warfarin. Explore more fluconazole interactions with GoodRx.
Fluconazole/warfarin interaction. Sublingual and retropharyngeal haematoma following warfarin overdose and interaction: case report. Erschienen in: Reactions
Comments
Not everyone wants to read about fucking and fucking and fucking and fucking and fucking and fucking and fucking and fucking and fucking and fucking.