DMARDs hydroxychloroquine (Plaquenil) leflunomide (Arava) methotrexate (Trexall) sulfasalazine (Azulfidine)
Leflunomide– Like sulfasalazine, leflunomide is used either in combination or in place of methotrexate in methotrexate cannot be used. Plaquenil– Plaquenil
Methotrexate Self-Injecting Methotrexate for the Treatment of Arthritis Hydroxychloroquine (brand name Plaquenil, Plaquenil Sulfate) is a medicine
The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate. Concomitant use of PLAQUENIL and methotrexate may increase the incidence of adverse reactions. Cyclosporine. An increased plasma cyclosporin level was reported when cyclosporin and PLAQUENIL were co-administered.
Medications for Rheumatoid Arthritis Hydroxychloroquine-Plaquenil: Sulfasalazine Azulfidine: Methotrexate Leflunomide:
The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate. Concomitant use of PLAQUENIL and methotrexate may increase the incidence of adverse reactions. Cyclosporine. An increased plasma cyclosporin level was reported when cyclosporin and PLAQUENIL were co-administered.
Methotrexate and hydroxychloroquine (Plaquenil) are both commonly used in the treatment of rheumatic diseases, particularly Rheumatoid Arthritis. They were initially approved by the FDA decades apart; methotrexate in 2024 and Plaquenil in 2024.
Concomitant use of PLAQUENIL and methotrexate may increase the incidence of adverse reactions. Discontinue PLAQUENIL if muscle or nerve toxicity is suspected
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