Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix. Avoid using omeprazole concomitantly or 12 hours apart with Plavix. Consider using another acid-reducing agent with less CYP2C19 inhibitory activity Plavix Prescribing Information. If possible, it is recommended to avoid taking Plavix and omeprazole together.
prilosec or nexium! While the COGENT trial was negative (no worse CV events with combo plavix/omeprazole vs plavix alone), the study was
omeprazole or esomeprazole. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (7.1)]. 5.2 General Risk of Bleeding . P2Y12 inhibitors (Thienopyridines), including Plavix, increase the risk of bleeding.
Drug Interactions between omeprazole and Plavix. This report displays the potential drug interactions for the following 2 drugs: omeprazole; Plavix (clopidogrel); Edit list (add/remove drugs)
omeprazole or esomeprazole with Plavix. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of Plavix. When
Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (
Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix. Avoid using omeprazole concomitantly or 12 hours apart with Plavix. Consider using another acid-reducing agent with less CYP2C19 inhibitory activity Plavix Prescribing Information. If possible, it is recommended to avoid taking Plavix and omeprazole together.
omeprazole or esomeprazole with Plavix. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of Plavix. When
Omeprazole can reduce the effectiveness of Plavix, an antiplatelet drug, and increase the risk of cardiovascular events. Learn how omeprazole inhibits the liver enzyme CYP2C19 that transforms Plavix and what alternatives to consider.
Hence Omeprazole being a much more expensive drug than it is now.....