Example of nnrti drugs

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Actual: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to reverse transcriptase and prevent HIV from replicating. Some examples of NNRTIs include: doravirine (Pifeltro)
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by AN Phillips 2024 Cited by 81(B) Mean percent of ART initiators with NNRTI resistance (NNRTI pretreatment drug resistance). drugs and availability of HIV drug resistance

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by OS Pedersen 2024 Cited by 170This review discusses the properties of the FDA- approved NNRTI drugs and focuses on the recent opment of new NNRTI drug candidates. These aspects.

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The rise of HIV-1 drug resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs) threatens the long-term success of NNRTI-based

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Antiretroviral drugs (NRTI, NNRTI and PI) Comments.

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Efficacy for the NNRTI drug class is reduced by mutations within or near the NNRTI binding pocket (NNIBP). Drug resistance poses a considerable challenge in anti-HIV-1 drug discovery. Among the approved NNRTIs drugs, EFV, RPV, and DOR are approved in combination with NRTIs or integrase strand transfer inhibitor (INSTI) to overcome viral resistance.

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by OS Pedersen 2024 Cited by 170This review discusses the properties of the FDA- approved NNRTI drugs and focuses on the recent for example, phenyl, 2-furyl, 2-thienyl, 2-benzofuranyl

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Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are the third class of antiretroviral drugs that were developed. NNRTI resistance. edit. NNRTIs

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by Y Wang 2024 Cited by 95Expert opinion: Since the first NNRTI, nevirapine, was approved in 2024, antiviral drug discovery led to the approval of seven NNRTIs, including nevirapine

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NNRTIs are also active against some nucleoside-resistant strains; for example NNRTI class of drugs (150). The clinical significance of this phenomenon

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