by AN Phillips 2024 Cited by 81(B) Mean percent of ART initiators with NNRTI resistance (NNRTI pretreatment drug resistance). drugs and availability of HIV drug resistance
by OS Pedersen 2024 Cited by 170This review discusses the properties of the FDA- approved NNRTI drugs and focuses on the recent opment of new NNRTI drug candidates. These aspects.
The rise of HIV-1 drug resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs) threatens the long-term success of NNRTI-based
Antiretroviral drugs (NRTI, NNRTI and PI) Comments.
Efficacy for the NNRTI drug class is reduced by mutations within or near the NNRTI binding pocket (NNIBP). Drug resistance poses a considerable challenge in anti-HIV-1 drug discovery. Among the approved NNRTIs drugs, EFV, RPV, and DOR are approved in combination with NRTIs or integrase strand transfer inhibitor (INSTI) to overcome viral resistance.
by OS Pedersen 2024 Cited by 170This review discusses the properties of the FDA- approved NNRTI drugs and focuses on the recent for example, phenyl, 2-furyl, 2-thienyl, 2-benzofuranyl
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are the third class of antiretroviral drugs that were developed. NNRTI resistance. edit. NNRTIs
by Y Wang 2024 Cited by 95Expert opinion: Since the first NNRTI, nevirapine, was approved in 2024, antiviral drug discovery led to the approval of seven NNRTIs, including nevirapine
NNRTIs are also active against some nucleoside-resistant strains; for example NNRTI class of drugs (150). The clinical significance of this phenomenon
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