Butorphanol (IM/IV): 2.0 Codeine (IM/IV): 120 Codeine (PO): 200 Fentanyl (IM/IV): 0.1 Fentanyl (Transdermal): 0.2 Hydrocodone (PO): 30 Hydromorphone (IV/IM/SC): 1.5 Hydromorphone (PO): 7.5 Levorphanol (acute PO): 4.0 Levorphanol (chronic PO): 1.0 Meperidine (IV/IM/SC): 75: Meperidine (PO): 300 Methadone (acute IV): 5.0 Methadone (acute PO): 10
Name ; Meperidine PO, IM, SubQ: 10 to 15. IV: ≤5. PO, IM, SubQ: 2 to 4. IV: 2 to 3 ; Methadone PO: 30 to 60. IV: 10 to 20. Acute: 4 to 6. Chronic: 8 ; Morphine.
♢ Methadone accumulates with repeated dosing. Chronic dosing Conversion from IV to PO: Example Morphine 10 mg IV = 30 mg PO (multiple by
Parenteral Methadone: Dosing. 1. Convert opioid to oral methadone dose equivalent. 2. TDD of IV methadone is 50% of the TDD of PO methadone. 3
IV to PO Conversion: Hydromorphone IV : PO = 1 : 5; Methadone IV : PO = 1 : 0.7. Current Infusion Dose Recommended Scheduled Dosing PRN Dosing Midazolam Drip IV Lorazepam (Max Dose: 4 mg) PRN IV Lorazepam (Max Dose: 4 mg)
Meperidine. PO. 1 mg ; Methadone. IV. 1mg ; Methadone. PO. 1mg ; Morphine. IV. 1 mg ; Morphine. Epidural. 1 mg.
Hydromorphone (IV/IM/SC): 1.5 Hydromorphone (PO): 7.5 Levorphanol (acute PO): 4.0 Levorphanol (chronic PO): 1.0 Meperidine (IV/IM/SC): 75: Meperidine (PO): 300 Methadone (acute IV): 5.0 Methadone (acute PO): 10 Methadone (chronic PO): see table above Morphine (IV/IM/SC): 10 Morphine (acute PO): 60 Morphine (chronic PO): 30 Nalbuphine (IV/IM/SC
How would you replace it? – Equianalgesic: Morphine 30mg PO = Dilaudid 1.5mg IV – Methadone 8 mg PO = Methadone X mg PO IV. Morphine 1mg PO Morphine
Butorphanol (IM/IV): 2.0 Codeine (IM/IV): 120 Codeine (PO): 200 Fentanyl (IM/IV): 0.1 Fentanyl (Transdermal): 0.2 Hydrocodone (PO): 30 Hydromorphone (IV/IM/SC): 1.5 Hydromorphone (PO): 7.5 Levorphanol (acute PO): 4.0 Levorphanol (chronic PO): 1.0 Meperidine (IV/IM/SC): 75: Meperidine (PO): 300 Methadone (acute IV): 5.0 Methadone (acute PO): 10
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