Seizure inducing drugs
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by AW Hitchings Cited by 31Drugs with the opposite effects may induce seizures. The propensity of a drug to induce seizures depends on its effects on neurotransmission and their time-.
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Drug-induced seizures can arise in the setting of acute drug withdrawal or drug toxicity, or as a consequence of medication use for acute illness in patients with no prior history of seizures. It has been long recognized that the antidepressants cause drug-induced seizures by lowering seizure threshold particularly at supratherapeutic levels.
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Most drug-induced seizures are self-limiting and do not result in severe sequelae. About 15% may present as status epilepticus, and this has potential for morbidity. The treatment of drug-induced seizures is usually like that of seizures due to other causes, although drug-induced seizures are more difficult to control.
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Drug-induced seizures can arise in the setting of acute drug withdrawal or drug toxicity, or as a consequence of medication use for acute illness in patients with no prior history of seizures. It has been long recognized that the antidepressants cause drug-induced seizures by lowering seizure threshold particularly at supratherapeutic levels.
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Generalized seizure is the type of seizure usually prevalent if the seizure is drug-induced.2. The incidence of seizure induced by wellbutrin is 0.35-0.44%.
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Many prescription drugs can lead to seizures. In fact, prescription drugs are a leading cause of drug-induced seizures.
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Some drug-induced seizures require specific treatment, such as the use of haemoperfusion or haemodialysis for theophylline neurotoxicity, or pyridoxine for isoniazid-induced seizures. If a firm diagnosis of drug-induced seizure is made, the use of that drug should be discontinued.
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3 Drug- induced seizures are diffuse and pathologi- cally different than idiopathic seizure. Thus, treatment of drug-induced seizure and status epilepticus
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3 Drug- induced seizures are diffuse and pathologi- cally different than idiopathic seizure. Thus, treatment of drug-induced seizure and status epilepticus
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