Glycoprotein 2b 3a inhibitor drugs

by M Srinivasan 2024 Cited by 12Amiodarone inhibits cytochrome P450 (CYP) enzymes 3A and 2C and the drug transporter P-glycoprotein. This leads to impaired metabolism and

Amiodarone is an Antiarrhythmic. The mechanism of action of amiodarone is as a Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 1A2 Inhibitor, and Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor.

- LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC absorption after bariatric surgery - Cytochrome P450 3A inhibitors and inducers

- LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC absorption after bariatric surgery - Cytochrome P450 3A inhibitors and inducers

During platelet activation glycoprotein 2b/3a (GP Iib/IIIa) receptors are activated allowing fibrinogen molecules and Von Willebrand factor link adjacent platelets to form an aggregate. The process of aggregation takes place within seconds of the injury, binding the platelets together that ultimately results in the formation of a thrombus

The Most Important Antiplatelet Drugs COX-2 inhibitor / Cyclooxygenase inhibitors Phosphodiesterase inhibitors Glycoprotein IIB/IIIA

Amiodarone is an Antiarrhythmic. The mechanism of action of amiodarone is as a Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450

Tirofiban is a nonpeptide, small molecule inhibitor of glycoprotein IIb/IIIa receptors. In acute coronary syndromes, the glycoprotein IIb/IIIa inhibitors

(Cymbalta), bupropion (Wellbutrin) and risperidone. (Risperdal). Now c/o Ritonavir/nirmatrelvir (Paxlovid) – inhibits P450 3A and p-glycoprotein causing.