Lung surfactant drugs

by MZ Islam 2024Understanding the molecular interaction of corticosteroid drugs with the lung surfactant monolayer is critical for the effective dosing and

This study investigated the influence of lung surfactant, DPPC, on the aerosolization of a first line hydrophilic anti-TB drug, pyrazinamide and a second line

, Azole drugs (like ketoconazole and to a lesser extent Surfactant therapy in acute lung injury/acute respiratory distress syndrome.

Endogenous lung surfactant is essential for effective ventilation because it modifies alveolar surface tension, stabilizing the alveoli. Lung surfactant

by M Rachid 2024 Cited by 1C43 DRUG INDUCED LUNG DISEASE: CASE REPORTS. Washington Daptomycin binds the lung surfactant irreversibly and may act like an antigen.

⚠️ Daptomycin is inactivated by surfactant in lung, so it cannot be used for pulmonary infection. Additional discussion: Drug-resistant

Endogenous lung surfactant is essential for effective ventilation because it modifies alveolar surface tension thereby stabilizing the alveoli. Lung surfactant deficiency is the cause of Respiratory Distress Syndrome (RDS) in premature infants. Infasurf restores surface activity to the lungs of these infants.

The interaction between the endogenous lung surfactant and pharmaceutical drugs has been previously described in the literature. In 2024, Silverman et al

Drugs added to surfactant should not impair innate surfactant function. Pulmonary surfactants serve a critical role in maintaining newly gained lung volume and gas exchange after birth. Through active reduction of surface tension, pulmonary surfactants prevent alveolar collapse at the end of expiration and facilitate continuous gas exchange.