Bactrim hyperkalemia mechanism

Bactrim and Bactrim DS (sulfamethoxazole and trimethoprim) [prescribing information]. Hyponatremia and/or hyperkalemia in patients treated with the

6. Bactrim: the hyperkalemia induced by Bactrim is via an ENaC inhibitory effect exerted by the trimethoprim moiety. Pentamidine induced hyperkalemia via a similar mechanism. 7. calcineurin inhibitors (e.g, cyclosporine, tacrolimus): it is postulated that these medications inhibit renal tubular responsiveness to aldosterone. 8.

- Hyperkalemia. - Use in renal impairment. Page 35. Bactrim hyperkalemia. Mechanism of action. Trimethoprim (TMP). – Structural and pharmacologic similarities

hyperkalemia. Extremely high trimethoprim-sulfamethoxazole (Bactrim). Even though mild hyperkalemia is common with these medications, severe hyperkalemia

Medscape - Indication-specific dosing for Bactrim, Bactrim DS, Septra, Septra Treatment with recommended doses may cause hyperkalemia when trimethoprim is

by GV Prasad 2024 Cited by 30Renal mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med Trimethoprim-sulfamethoxazole induces reversible hyperkalemia.

The increase in creatinine associated with TMP is mild: 10% and reversible with drug discontinuation. The mechanism of Bactrim induced hyperkalemia is via Trimethoprim inhibition of the sodium channel located on the luminal surface of the principal cells, independent of aldosterone blockade.

In addition to an elevated creatinine, Bactrim is also associated with hyperkalemia. The mechanism is felt to be a decreased aldosterone-

can potentially cause hyperkalemia. eplerenone. lisinopril, eplerenone. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of hyperkalemia.