Pill wiz

☑️@pill_wiz · 6232 subscribers · Content 18+ 🔞
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Actual: WIZ degradation is mediated by recruitment of WIZ(ZF7) to CRBN by dWIZ-1, as resolved by crystallography of the ternary complex. Pharmacological degradation of WIZ was well tolerated and induced HbF in humanized mice and cynomolgus monkeys. These findings establish WIZ degradation as a globally accessible therapeutic strategy for SCD.
4.8 rating 2025-04-24
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WIZ is a core component of the repressive G9a–G9alike protein (GLP) histone methyltransferase complex (also called the EHMT1-EHMT2 complex). The authors propose that WIZ thereby acts as a negative regulator of HbF expression by reducing the repressive histone H3 Lys 9 (H3K9) dimethylation at the promoters of the HBG1 and HBG2 genes. Thus

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The Wiz is a passive item added in The Binding of Isaac: Afterbirth. Isaac fires tears from both eyes at the same time. Isaac's tears are fired diagonally outwards, similar to the effect of the R U a Wizard? pill. Isaac's tears become spectral. The maximum amount of tears per volley that can be reached by combining and/or duplicating 20/20, The Inner Eye, Mutant Spider and The Wiz is 16. The

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