Acyclovir is slowly and poorly absorbed from the gastrointestinal tract and bioavailability decreases with increasing dose. Acyclovir is widely distributed into tissues and body fluids. Plasma protein binding is relatively low at 9 to 24%. Renal excretion is the major route of elimination of acyclovir. Adverse Effects:
Acyclovir is 15% oxidized to 9-carboxymethoxymethylguanine by alcohol Drink plenty of fluids. Dehydration with acyclovir predisposes patients to
Acyclovir was discontinued on the suspicion of acyclovir neurotoxicity. Even though PCR for varicella zoster virus in the cerebrospinal fluid was positive, acyclovir was not restarted and the patient continued to improve and returned to her baseline.
Take acyclovir by mouth with or without food, usually 2 to 5 times a day as directed by the doctor. Drink plenty of fluids while taking acyclovir unless your
There was a less than dose-proportional increase in acyclovir maximum Be sure to drink plenty of fluids during this time. If you miss a dose of
acyclovir and continuing for six hours after the acyclovir increases the concentration of methotrexate in tubular fluid). In
The dose of valacyclovir can be increased to 1 g daily for those with breakthrough recurrences. acyclovir therapy and intravenous fluids. Such
Intravenous fluids may be as quickly as possible. 8, 22, 36, 37 Acyclovir should be added if there loss was 21. 38, 41 There was a small increase in recurrent fever
by OL Laskin 2024 Cited by 152Acyclovir enters the cerebrospinal fluid. saliva and vaginal secretions at increase in the plasma acyclovir levels with therapy (fig. 4a). However
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Saunas: heat, sweat, and other bodily fluids.