Acarbose vs metformin

by R Zhang 2024 Cited by 3In China, the first head-to-head study comparing the therapeutic efficacy of acarbose and metformin (MARCH study) confirmed that acarbose was

The difference in the effects of acarbose vs. placebo and metformin vs. placebo were statistically significant, but those of acarbose vs. metformin were not . On the other hand, our results are in agreement with Van de laar et al. who reported alpha-glucosidase inhibitors reduce postprandial hyperglycemia, delaying the breakdown of

The LDL-C to HDL-C ratio decreased 26.7% with acarbose, was unaltered by metformin, and by 14.4% in the placebo group (p=0.0013 for acarbose vs placebo; p=0.0311 for acarbose vs metformin). 94 Another study by Willms and Ruge 95 showed that acarbose and metformin therapy had similar outcomes regarding TC concentration ( 0.23 mM for both), but

Conclusion: The glucose lowering effects of metformin monotherapy and acarbose monotherapy are the same by direct comparison, while metformin is a little better

and their positioning in the treatment process. syndrome, metformin, sulphonylureas, meglitinides. thiazolidinediones, acarbose, insulin.

The present study revealed a 77% reduction in hypoglycemic events with the addition of acarbose vs sulfonylureas to metformin treatment of T2D. Acarbose has been associated with a lower incidence of hypoglycemia and an absence of weight gain compared with other OHAs, such as sulfonylureas, meglitinides, thiazolidinediones, and insulin ( 40 ).

The C max of glucose after an oral sucrose load was reduced on average by about 17%, 22%, and 21% after treatment with acarbose/metformin FDC, acarbose/metformin LC, and acarbose alone, whereas no effect was seen for metformin alone. 20 There was a minor reduction in AUC (0-4h) for PPG by about 3% after intake of the acarbose-containing drugs

The difference between pre- and posttreatment levels of the 2-h PPBG level in both arms of the study were statistically significant ( -acarbose, 5.3 0.4 vs. ff-metformin, 2.9 0.3) (P 0.05). Specific drug-associated side effects were observed in 12 patients on acarbose and 3 patients on metformin.

The study is based on metformin hydrochloride and acarbose (the active ingredients of Metformin and Acarbose, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.