Fluconazole and warfarin

☑️@fluconazole_and_warf · 6220 subscribers · Content 18+ 🔞
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Actual: Fluconazole significantly reduces the metabolic clearance of warfarin and dramatically increases the magnitude and duration of warfarin's hypothrombopenic
4.3 rating 2025-04-24
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Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin dose reduction for extended course. ; Fluoroquinolones, ↑. Not always clinically

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Amiodarone. Increase. Decreases warfarin metabolism ; Antifungal agents. Increase. Fluconazole, ketoconazole, and miconazole (vaginal) decrease warfarin

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Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin dose reduction for extended course. ; Fluoroquinolones, ↑. Not always clinically

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Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin dose reduction for extended course. ; Fluoroquinolones, ↑. Not always clinically

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For example, when warfarin is given concomitantly with fluconazole, a potent inhibitor of CYP2C9, fluconazole will inhibit warfarin's

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Amiodarone. Increase. Decreases warfarin metabolism ; Antifungal agents. Increase. Fluconazole, ketoconazole, and miconazole (vaginal) decrease warfarin

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Fluconazole, ↑. Hold warfarin x1 for single dose. Expect % warfarin Metronidazole (Flagyl), ↑. Expect % warfarin dose reduction. Phenytoin

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Perioperative management of warfarin is covered in the BC Guideline Warfarin Therapy – Management During Invasive o fluconazole o itraconazole.

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warfarin dose if needed. fluconazole. fluconazole will increase the level or effect of warfarin by affecting hepatic enzyme CYP2C9/10 metabolism. Modify

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