Celecoxib cox 1 or 2

inhibition of prostaglandin synthesis, primarily via selective inhibition of cyclooxygenase-2 (COX-2) and at therapeutic concentrations in humans, celecoxib is not highly effective in inhibiting the cyclooxygenase-1 (COX-1) isoenzyme. Celecoxib is times more selective for COX-2 compared to COX-1.

fold selectivity for COX-2 over COX-I .? The methylphenyl ring of celecoxib binds to 1 site on the COX-2 isoenzyme, and the benzenesulfonamide ring binds to another site found on the COX-2 but not the COX- 1 isoenzyme.38 Celecoxib s selec- tivity appears to result from the phenyl- sulfonamide moiety.

Selective COX-2 inhibitors are NSAIDs that block more COX-2 than COX-1. Celecoxib (Celebrex) is currently the only selective COX-2 inhibitor available by

Celecoxib is a COX-2 inhibitor. The cyclooxygenase (COX) enzymes catalyze pathways that play a key role in the generation of the inflammatory response. Most NSAIDs inhibit both types of cyclooxygenase, COX-1 and COX-2, while celecoxib selectively inhibits COX-2. Celecoxib is primarily metabolized by CYP2C9.

COX-1 vs. COX-2 inhibition Although not labelled as COX-2 selective inhibitors, both meloxicam and etodolac are more COX-2 selective than celecoxib.

COX-2: COX-1 น้อยกวา่ 0.01 ยากลุ่มน้ีที่ยงัไม่ถูกถอนออกจากตลาดไดแ้ก่celecoxib, parecoxib และetoricoxib

Selective NSAIDs, like celecoxib, are called COX-2 inhibitors. They block COX-2 more strongly than they block COX-1. Aspirin blocks both COX-1

The enzyme cyclooxygenase exists in two different isoforms: COX-1 and COX-2. medications like ibuprofen, and selective COX-2 inhibitors like celecoxib.

Secara farmakologi, diclofenac berbeda dengan celecoxib. Diclofenac menghambat enzim COX-1 dan COX-2, sedangkan celecoxib hanya menghambat enzim