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Author: Admin | 2025-04-28
Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. JAMA. 2019;321(6):562-571. doi:10.1001/jama.2018.22039,15Abushanab D, Al-Badriyeh D. Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis. CNS Drugs. 2021;35(1):105-120. doi:10.1007/s40263-020-00777-7: One dose of acetaminophen (325 mg), and One dose of ibuprofen (200 mg) You can alternate the drugs by taking 1 to 2 doses of the first medication and then 1 to 2 doses of the second medication 3 hours later.2Tylenol Regular Strength. Package Insert. Johnson & Johnson Consumer Inc; 2023,6Motrin IB. Package Insert. Johnson & Johnson Consumer Inc; 2023 For example: Take acetaminophen (325 mg to 500 mg), then Take ibuprofen (200 mg to 400 mg) 3 hours later Continue to alternate every 3 hours Combining the two medications targets pain through two distinct modes of action (pain perception and inflammation), which produces a stronger pain-relieving effect than taking only acetaminophen or ibuprofen.13Casiano VE, Sarwan G, Dydyk AM, et al. Back Pain. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538173/ ,14Thybo KH, Hägi-Pedersen D, Dahl JB, et al. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. JAMA. 2019;321(6):562-571. doi:10.1001/jama.2018.22039However, combining NSAIDs (ibuprofen, naproxen, and magnesium salicylate) with other NSAIDs is not recommended due to the significantly increased risk of adverse events and complications.5Ngo VTH, Bajaj T. Ibuprofen. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542299/ Combination OTC products on the marketSome medications are preformulated with acetaminophen and ibuprofen, including: Advil Dual Action Motrin Dual Action with TylenolThese combination products contain 250 mg of acetaminophen and 125 mg of ibuprofen in each tablet. You can take 1 to 2 doses every 8 hours.16Motrin Dual Action With Tylenol. Package Insert. Johnson & Johnson Consumer Inc; 2023,17Advil Dual Action With Acetaminophen. Package Insert. GlaxoSmithKline Consumer Healthcare Holdings (US) LLC; 2022 Long term use of OTC pain medications When using OTC products for self-medication, using these medications for longer than 10 days is not recommended without consulting a healthcare provider to address the underlying cause.2Tylenol Regular Strength. Package Insert. Johnson & Johnson Consumer Inc; 2023,6Motrin IB. Package Insert. Johnson & Johnson Consumer Inc; 2023,8Aleve Back and Muscle Pain. Package Insert. Bayer HealthCare LLC; 2022It is also important to talk to a doctor if your back pain is severe, persistent, or accompanied by other concerning symptoms, such as numbness or weakness, which may indicate a more severe underlying condition. 1 Gerriets V, Anderson J, Nappe TM. Acetaminophen. [Updated 2022 Sep 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482369/ 2 Tylenol Regular Strength. Package Insert. Johnson & Johnson Consumer Inc; 2023 3 Tylenol Extra Strength. Package Insert. Johnson & Johnson Consumer Inc; 2023 4 Tylenol 8HR. Package Insert. Johnson & Johnson
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