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Author: Admin | 2025-04-28
Abilify (aripiprazole) and Rexulti (brexpiprazole) are brand-name drugs. They’re both prescribed for schizophrenia and major depressive disorder.This article explains the main similarities and differences between Abilify and Rexulti. If you’re considering taking one of these drugs, discussing this information with your doctor can help you decide whether one of these treatments may be right for you.Note: For more comprehensive information about these two drugs, you can refer to our Abilify and Rexulti articles.Key differences between Abilify and RexultiThese are a few of the main differences between Abilify and Rexulti:Form: Abilify and Rexulti come as oral tablets. Abilify also comes in other forms under the brand names Abilify MyCite, Abilify Asimtufii, and Abilify Maintena. (See “Dosages, forms, and administration” below.) Unless otherwise stated, this article mainly focuses on the oral tablet form of Abilify.Conditions treated: Abilify and Rexulti are both used to treat schizophrenia and major depressive disorder (MDD), commonly referred to as depression. Both drugs are also used to treat other conditions. (See “Uses of Abilify vs. Rexulti” below.)Below are answers to some common questions about Abilify and Rexulti.Does weight gain with Abilify or Rexulti differ?No, weight gain with Abilify or Rexulti doesn’t appear to differ.Both Abilify and Rexulti may cause weight gain. One study found that Abilify and Rexulti had a similar effect on body weight after the medications were taken for 1 year.To learn more about weight gain with these drugs, you can refer to the prescribing information for Abilify and Rexulti. Your doctor can also provide more details.How do Abilify and Rexulti compare with Vraylar?Below are a few ways Abilify and Rexulti compare with the drug Vraylar.* The uses listed for Abilify are for the oral tablet form. These differ from the approved uses for the other forms of Abilify. For more information, see the prescribing information for Abilify Asimtufii, Abilify MyCite, and Abilify Maintena.† “Extended release” means the drug is slowly released into the body over a long period of time.‡ The frequency of Abilify applies to the oral tablet forms of the drug, including Abilify MyCite.To learn more about how Abilify and Rexulti compare with Vraylar, talk with your doctor.Abilify and Rexulti have been approved by the Food and Drug Administration (FDA) to treat the following.Both Abilify and Rexulti are FDA-approved to treat:schizophrenia in adultsmajor depressive disorder in adults, when used in combination with an antidepressantAbilify is also FDA-approved to treat:manic and mixed episodes in adults with bipolar I disorder, either alone or in combination with lithium (Lithobid) or valproateRexulti is also FDA-approved to treat:agitation from dementia related to Alzheimer’s diseaseAbilify or Rexulti and childrenAbilify and Rexulti have been approved by the FDA to treat the following conditions in children.Both Abilify and Rexulti are FDA-approved
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