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Author: Admin | 2025-04-28
The effects on serotonin, amitriptyline and Adderall can increase concentrations of another neurotransmitter, norepinephrine. Norepinephrine can increase blood pressure and heart rate. Therefore, taking both amitriptyline and Adderall could increase the risk of cardiovascular effects.Having said all of the above, tricyclic antidepressants like amitriptyline and amphetamine products are used in combination together in practice fairly often. In fact, several studies suggest the combination of antidepressants like amitriptyline and stimulants like Adderall can be very effective, and relatively safe, for the treatment of 'treatment-resistant depression'.Just how risky the combination isn't well known. Most studies that discuss serotonin syndrome as a general topic will list both tricyclic antidepressants and stimulants as potential causative factors. Nevertheless, the risk appears relatively low for most people taking amitriptyline and Adderall specifically. While caution should be exercised when using both of these drugs, the combination is considered a lower risk than others since the serotonin effects of amphetamine and amitriptyline aren't all that strong. While amitriptyline does have some effects as a serotonin reuptake inhibitor, it is classified as a weak inhibitor. One study, published in the Canadian Family Physician, states the following:References Elsevier ClinicalKey: Adderall (Accessed 1/21/19) Elsevier ClinicalKey: Elavil (Accessed 1/21/19) Serotonin syndrome and other serotonergic disorders. PubMed (Accessed 1/21/19) Serotonin Syndrome. PubMed (Accessed 1/21/19)Demystifying serotonin syndrome (or serotonin toxicity). PubMed (Accessed 1/21/19) The scoop on serotonin syndrome. PubMed (Accessed 1/21/19) Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. PubMed (Accessed 1/21/19) The scoop on serotonin syndrome.
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