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Author: Admin | 2025-04-28
Brand Names Associated with Simvastatin Flolipid® Juvisync® (as a combination product containing Simvastatin, Sitagliptin) Simcor® (as a combination product containing Niacin, Simvastatin) Simvastatin Vytorin® (as a combination product containing Ezetimibe, Simvastatin) Zocor® Brand Names Associated with Amlodipine Amlodipine Amvaz® Azor® (as a combination product containing Amlodipine, Olmesartan) Caduet® (as a combination product containing Amlodipine, Atorvastatin) Consensi® (as a combination product containing Amlodipine, Celecoxib) Exforge® (as a combination product containing Amlodipine, Valsartan) Exforge® HCT (as a combination product containing Amlodipine, Hydrochlorothiazide, Valsartan) Katerzia® Norvasc® Prestalia® (as a combination product containing Amlodipine, Perindopril) Tribenzor® (as a combination product containing Amlodipine, Hydrochlorothiazide, Olmesartan) Twynsta® (as a combination product containing Amlodipine, Telmisartan) Medical Content Editor Last updated Mar 03, 2024 Curious for more information about this interaction? Ask our pharmacists directly! Reach out to us Interaction Effect Increased simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Interaction Summary Concurrent administration of amlodipine and simvastatin increases simvastatin exposure and may increase the risk of myopathy or rhabdomyolysis[1]. If it is necessary to coadminister amlodipine and simvastatin, the dose of simvastatin should not exceed 20 mg/day [2][1]. Severity Major Onset Rapid Evidence Probable How To Manage Interaction Concurrent administration of amlodipine and simvastatin increases simvastatin exposure and may increase the risk of myopathy or rhabdomyolysis[1]. If it is necessary to coadminister amlodipine and simvastatin, the dose of simvastatin should not exceed 20 mg/day [2][1]. Mechanism Of Interaction Unknown Literature Reports A) Simvastatin AUC and Cmax increased with coadministration of simvastatin and amlodipine in a pharmacokinetic study. Subjects received amlodipine 10 mg every day for 10 days and on day 10 a single, 80-mg dose of simvastatin was administered. The mean ratio (with amlodipine/without amlodipine) of simvastatin was 1.77 for AUC and 1.47 for Cmax. The corresponding ratios for simvastatin acid (beta-hydroxyacid of simvastatin) were
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