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Author: Admin | 2025-04-28
Behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-chlorpheniramine were compared to triprolidine, a potent and selective H1 antagonist, and (-)-chlorpheniramine, which is less active than its enantiomer at H1 receptors. Affinities of the drugs at DA, serotonin, and norepinephrine transporters, at H1 receptors, and potencies for DA uptake inhibition in striatal synaptosomes were determined to assess mechanisms by which the compounds increased DA levels. Intravenous diphenhydramine (1.0-3.0 mg/kg), (+)- and (-)-chlorpheniramine (1.0-5.6 mg/kg), but not triprolidine (1.0-3.0 mg/kg) elicited a cocaine-like pattern of stimulation of DA transmission, with larger effects in the NAc shell than core. The absence of stereospecific effects with chlorpheniramine enantiomers, along with the lack of an effect with triprolidine suggest that the effects on DA transmission were not related to H1 receptor antagonism. Although in vivo potencies were not directly related to DA transporter affinities, it is hypothesized that actions at that site, modulated by other actions, possibly those at the serotonin transporter, are primarily responsible for the neurochemical actions of the drugs on DA neurotransmission, and might underlie the occasional misuse of these medications. cra$h Palladium Member Reputation Points: 1,266 Joined: Oct 21, 2007 from Philly dhp is nothing like coke, and you need like, 300+mg to get high. and as for snorting, wow, chewing them even stings like a motherfucker, couldn't imagine snorting. Last edited by a moderator: Sep 20, 2008 highguy Newbie Reputation Points: 15 Joined: Aug 27, 2008 from U.S.A. benadryl could help by making You forget he wants some coke.be warned. swim once snorted 300mgs of it and the pain.thought it would numb the nose but no, the pain multiplies with more.inhaling gasoline then lighting it then hittin a line of shattered glass just before the nose disenegrates would sound nice with that shit in the nose.no exagerationdxm can be stimulating at lower doses but at higher it becomes more of a trippy opoid from my experiences.a dxm fix will make You happy and beat the craving untill some coke appears dude otc medications are not worht it at ALL in swims opinion.hes done benadryl and dramamine and boith sucked bad. dxm didnt really float his boat either. u want a I think u oughta legal drug go to a head shop and get some kratom(fun and relaxing) or basically any heath food store and buy some kava kava root(not extract). both are safer and wayyyyyy more pleasurable than diph. u cant rail em but in swims opinion both are fun and worht it. Zaknafien Newbie Reputation Points: 3 Joined: Sep 4, 2008 as swihighguy has said although Diphenhydramine will not give you a stimulant buzz but quite the opposite. Profound Tiredness. But One would imagine the
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