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Author: Admin | 2025-04-28
HomeBenadrylSide Effects Generic name: diphenhydramineMedically reviewed by Drugs.com. Last updated on Oct 3, 2024. Professional infoFAQ Note: This document provides detailed information about Benadryl.Applies to diphenhydramine: oral capsules and tablets, parenteral injection Side Effects associated with diphenhydramine. Some dosage forms listed on this page may not apply specifically to the brand name Benadryl.Applies to diphenhydramine: oral capsules and tablets, parenteral injection.Side effects include:Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions. For healthcare professionalsApplies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating.General adverse eventsThe most commonly reported side effects included somnolence, dizziness, and incoordination.[Ref]Nervous systemCommon (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache, attention disturbanceRare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsionsFrequency not reported: Paresthesia, dyskinesia/muscle dyskinesia, vertigo, neuritis, incoordination, psychomotor impairment, activation of epileptogenic foci[Ref]Drowsiness usually diminishes after a few days.[Ref]GastrointestinalCommon (1% to 10%): Dry mouthFrequency not reported: Gastrointestinal disturbance, nausea, vomiting, constipation, diarrhea, dyspepsia, epigastric distress[Ref]OtherCommon (1% to 10%): FatigueFrequency not reported: Lassitude, tinnitus, acute labyrinthitis, asthenia, chills, impaired performance (including impaired driving, work, and/or information processing)[Ref]PsychiatricRare (0.01% to 0.1%): Confusion, depression, sleep disturbancesFrequency not reported: Paradoxical excitation/excitation, agitation, increased energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability[Ref]CardiovascularRare (0.01% to 0.1%): Palpitations, hypotension, arrhythmiaFrequency not reported: Tachycardia, chest tightness, extrasystoles[Ref]HematologicRare (0.01% to 0.1%): Blood disordersFrequency not reported: Hemolytic anemia, thrombocytopenia, agranulocytosis[Ref]HypersensitivityRare (0.01% to 0.1%): Hypersensitivity reactionsFrequency not reported: Angioedema, anaphylactic shock[Ref]HepaticRare (0.01% to 0.1%): Liver dysfunction[Ref]DermatologicFrequency not reported: Rash, urticaria, skin rashes, erythema, photosensitivity, pruritus, drug rash, excessive perspiration[Ref]RespiratoryFrequency not reported: Dyspnea, thickening of bronchial secretions, throat tightening, wheezing, nasal stuffiness, dry nose or throat[Ref]GenitourinaryFrequency not reported: Urinary hesitancy/difficulty/retention, dysuria, early menses[Ref]OcularFrequency not reported: Blurred vision, dry eyes, diplopia[Ref]MetabolicFrequency not reported: Increased appetite, anorexia[Ref]MusculoskeletalFrequency not reported: Muscle twitching/weakness[Ref]References1. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis2. (2022) "Product Information. Benadryl Children's Allergy Fastmelt (diphenhydrAMINE)." Pfizer U.S. Pharmaceuticals Group3. Cerner Multum, Inc. "UK Summary of Product Characteristics."4. Cerner Multum, Inc. "Australian Product Information."Frequently asked questionsWhat is the Benadryl hat man?What is the max dose of diphenhydramine for adults?How much Benadryl can I take? What is too much?Which antihistamines are safe for dogs?What are the effects of taking expired benadryl?How long does Benadryl take to work?Does Benadryl make you sleepy?Does Benadryl help with or cause anxiety?How much Benadryl can I give my dog?Further informationBenadryl side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.Medical Disclaimer
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