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Author: Admin | 2025-04-28
Disease to improve exercise tolerance shown by increased 6-minute walk test and increases time to clinical worsening. It has been shown to improve patient compliance due to the once a day dosing. It is not to be used with concurrent use of organic nitrates in any form. Patient are often monitored directly by a physician during their first dosing as it can cause low blood pressure. Calcium Channel Blockers Diltiazem and Nifedipine (and more recently amlodipine) are used in some patients with pulmonary hypertension. Enthusiasm for this class of medications has decreased over the past few years. Approximately 10% of patients may benefit in the short term, and even fewer over the long term. Patients with Raynaud's (painful color change of the fingers on exposure to cold) often find their symptoms improved while on calcium channel blockers. Blood Thinners Warfarin (Coumadin) is prescribed for most patients with pulmonary arterial hypertension. There is some data from research studies that this medication may improve survival as patients with PAH are at increased risk to develop blood clots. It requires monitoring to adjust the dose. There are many medications and foods that interact with warfarin. In general, patients on Warfarin should avoid aspirin containing products. Diuretics Most if not all patients with pulmonary hypertension will require a diuretic to prevent retention of salt and water. Commonly prescribed agents include furosemide (Lasix), bumetinide (Bumex), and spironolactone (Aldactone). These medications are usually prescribed once daily initially, but in patients with more advanced disease, escalated dosing
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