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Author: Admin | 2025-04-28
Physician who elects to use buspirone hydrochloride tablets for extended periodsshould periodically reassess the usefulness of the drug for the individual patient. Dosage for BusparThe recommended initial dose is 15 mg daily (7.5 mg b.i.d.). To achieve an optimal therapeuticresponse, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maximumdaily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided dosesof 20 mg to 30 mg per day were commonly employed.The bioavailability of buspirone is increased when given with food as compared to the fasted state (see CLINICAL PHARMACOLOGY). Consequently, patients should take buspirone in a consistent mannerwith regard to the timing of dosing; either always with or always without food.When buspirone is to be given with a potent inhibitor of CYP3A4, the dosage recommendationsdescribed in the DRUG INTERACTIONS section should be followed.HOW SUPPLIEDBuspirone Hydrochloride Tablets USP, 5 mg are white to off-white, capsule-shaped, flat- faced,beveled-edge tablets debossed with bisect on one side; one side of bisect is debossed with 'ZE' andanother is debossed with '36' and other side is plainManufacturer details: N/A. Revised: May 2016 Side Effects for BusparNo information provided.Drug Interactions for BusparPsychotropic AgentsMAO InhibitorsIt is recommended that buspirone hydrochloride tablets not be used concomitantly with MAO inhibitors (see WARNINGS).AmitriptylineAfter addition of buspirone to the amitriptyline dose regimen, no statistically significant differences in the steady-state pharmacokinetic parameters (Cmax, AUC, and Cmin) of amitriptyline or its metabolite nortriptyline were observed.DiazepamAfter addition of buspirone to the diazepam dose regimen, no statistically significant differences in the steady-state pharmacokinetic parameters (Cmax, AUC, and Cmin) were observed for diazepam, but increases of about 15% were seen for nordiazepam, and minor adverse clinical effects (dizziness, headache, and nausea) were observed.HaloperidolIn a study in normal volunteers, concomitant administration of buspirone and haloperidol resulted in increased serum haloperidol concentrations. The clinical significance of this finding is not clear.Nefazodone[see Inhibitors and Inducers of Cytochrome P450 3A4 (CYP3A4)].TrazodoneThere is one report suggesting that the concomitant use of Desyrel®# (trazodone hydrochloride) and buspirone may have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients. In a similar study attempting to replicate this finding, no interactive effect on hepatic transaminases was identified.Triazolam/FlurazepamCoadministration of buspirone with either triazolam or flurazepam did not appear to prolong or intensify the sedative effects of either benzodiazepine.Other PsychotropicsBecause the effects of concomitant administration of buspirone with most
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