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Author: Admin | 2025-04-28
Dosing and Dilution of Perioperative Vasoactives Inotropes and Vasopressors Dopamine Infusion: 1-5 mcg/kg/min Dobutamine Infusion: 0.5-20 mcg/kg/min Epinephrine Infusion: 0.01-0.15 mcg/kg/min Bolus: 5-10mcg bolus; prepare 10-20mL syringe @ 10mcg/mL* *Bolus syringe may be taken from infusion bag then diluted to 8 mcg/mL Milrinone Infusion: 0.1-0.4 mcg/kg/min Loading dose (used sometimes): 25-50 mcg/kg slow bolus Norepinephrine Infusion: 0.02-0.1 mcg/kg/min (approx. 1-10mcg/min) Bolus: 4-8mcg bolus; prepare 20mL syringe @ 8 mcg/mL Phenylephrine Infusion: 0.2-1 mcg/kg/min Bolus: 100-200mcg bolus; prepare 10-20mL syringe @ 100mcg/mL Vasopressin Infusion: 0.01-0.04 units/min Bolus: 0.5-1 unit bolus; prepare 10-20ml syringe @ 1 unit/ml Vasodilators Clevidipine Infusion: 1-20mg/hr Bolus: 0.05-0.1mg bolus (0.05mg = 0.1mL); prepare undiluted 3mL syringe Nicardipine Infusion: 1-15 mg/hr Bolus: 50-100mcg bolus; prepare 10mL syringe @ 100mcg/mL Nitroglycerin Infusion: 0.2-2 mcg/kg/min Bolus: 50-100mcg boluses; prepare 20mL syringe @ 50mcg/mL Nitroprusside Infusion: 0.1-2 mcg/kg/min Bolus: rarely used. If necessary, 10-25mcg bolus; prepare 20mL syringe @ 20 or 25mcg/mL These dilutions and dosages are to be used as a guide and starting point. If it is a new drug to you or you are uncertain, check with your attending before administration. Stanford Cardiac Anesthesia, 2017
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