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Author: Admin | 2025-04-28
Published Sep 27, 2022 Last updated Mar 01, 2025 Key points There is no drug interaction between Benadryl (diphenhydramine) and Advil (ibuprofen). They can safely be taken together. AnswerYes, Benadryl (diphenhydramine) may be safely taken with Advil (ibuprofen). In fact, Advil PM is exactly this combination! Each dose of Advil PM contains 200 mg of ibuprofen and either 25 mg of diphenhydramine hydrochloride or 38mg diphenhydramine citrate.What Is Benadryl?Benadryl contains diphenhydramine, a sedating antihistamine marketed under many names, including Benadryl and ZzzQuil. Benadryl is well known for treating the itchiness resulting from allergic reactions to things like insect bites, laundry detergent, or poison ivy. It can be taken orally but also comes in a topical form. In addition to treating allergy symptoms, Benadryl can help with insomnia due to the sedation it causes.What Is Ibuprofen?Ibuprofen is an NSAID that is used to treat fever as well as pain and inflammation caused by headaches, muscle aches, arthritis, menstrual cramps, and toothaches to name a few. Ibuprofen comes in 200mg when sold over the counter. Ibuprofen comes in 400mg, 600mg, and 800mg when dispensed with a prescription. Ibuprofen is not recommended on a daily basis because it can cause stomach irritation or ulcers when taken chronically.Taking Benadryl With IbuprofenAs mentioned above, Advil and Benadryl are a safe combination and can be taken together at night.It is important to note that Benadryl can cause confusion and dizziness leading to falls in seniors, so it is not recommended for this population. It is also
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