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Author: Admin | 2025-04-28
Here.Free prescription couponsSeriously … free. Explore prices that beat the competition 70% of the time.Get free card3. AntidepressantsThere are many different kinds of antidepressants, and some of them can interact with Benadryl and other antihistamines. For example, tricyclic antidepressants (TCAs) mixed with antihistamines may increase the side effects of either, including constipation, dry mouth, and confusion. Examples of these include:amitriptyline (Elavil)clomipramine (Anafranil)imipramine (Tofranil)Some 2022 research found that diphenhydramine (Benadryl) can increase the side effects of different antidepressants, including:sertraline (Zoloft)paroxetine (Paxil)duloxetine (Cymbalta)The study also noted that older research suggested that diphenhydramine affects the metabolism of venlafaxine (Effexor). So it’s likely that Benadryl increases the concentration of antidepressants in your blood, meaning the risk of side effects is higher.Drowsiness is a common side effect of different kinds of antidepressants. Taking antidepressant medications and Benadryl can increase the sedative effects of both medications.Doctors can recommend how to take antidepressants and Benadryl to prevent increasing your risk of side effects. They can also advise about other alternative drugs that can replace Benadryl or your antidepressant medication that have a lower chance of interaction.4. MelatoninMelatonin is a hormone that your brain naturally produces. Melatonin increases sleepiness and promotes your sleep. It is available in the form of supplements that people often take when they have trouble sleeping or if they have a sleeping disorder. Increased drowsiness is a common side effect people experience when taking Benadryl. Taking Benadryl with melatonin supplements can cause excessive sleepiness, making it difficult to perform daily tasks. Melatonin has a moderate risk of interaction with Benadryl, and doctors do not typically recommend taking both medications at the same time, as well as other supplements that may make you more sleepy than usual. If you take Benadryl, it is best to speak with a doctor before taking melatonin.Safe medicationsTaking OTC medications, provided they are not antihistamines, is typically safe if you are using Bendaryl. But if you have any concerns about taking a new medication while using Benadryl, you can contact a doctor and ask them if it is safe for you to do so.OTC medications such as ibuprofen (Advil) and
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