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Author: Admin | 2025-04-28
Other NSAIDs while you’re taking celecoxib. This can make it difficult to find a pain reliever for minor aches and pains that’s safe to take with celecoxib. Talk with your doctor or pharmacist about safe ways to relieve pain during your celecoxib treatment.Certain antidepressantsCelecoxib can interact with SSRIs and SNRIs, which are types of antidepressants. These medications are also prescribed for other uses, including anxiety disorders and fibromyalgia.Interaction result: Taking celecoxib and certain antidepressants can increase the risk for serious GI side effects of celecoxib and certain antidepressants.Interaction explained: SSRIs and SNRIs can increase your risk of bleeding. Celecoxib has a boxed warning about the risk for serious GI side effects, including GI bleeding. Taking celecoxib with an SSRI or SNRI may further raise your risk for GI bleeding.Examples of SSRI and SNRI drugs: Here are some antidepressants that may interact with celecoxib:selective serotonin reuptake inhibitors (SSRIs), such as: sertraline (Zoloft)fluoxetine (Prozac)citalopram (Celexa)paroxetine (Paxil)serotonin-norepinephrine reuptake inhibitors (SNRIs), such as: duloxetine (Cymbalta)venlafaxine (Effexor XR)milnacipran (Savella)desvenlafaxine (Pristiq)Steps you or your doctor may take: If your doctor prescribes celecoxib and an SSRI or SNRI together, they’ll likely closely monitor you for symptoms of a GI bleed. While taking this combination, immediately contact your doctor if you notice symptoms of a GI bleed. Examples of symptoms to watch for include blood in your stool, spit, or vomit, confusion, and intense nausea. But seek immediate medical attention if your symptoms feel severe or life threatening.Certain blood pressure medicationsCelecoxib can interact with certain blood pressure medications. These medications are prescribed to treat high blood pressure, among other uses.Interaction result: Taking celecoxib with certain blood pressure medications can make certain blood pressure medications less effective. It can increase the risk for kidney-related side effects of NSAIDs and certain blood pressure medicationsInteraction explained: Celecoxib can make ACE inhibitors,
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