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Author: Admin | 2025-04-28
Combination therapy holds promise against biofilm-associated UTIs as it confers antibacterial, immunomodulatory and anti-inflammatory effects1. Ciprofloxacin vs Azithromycin for Chronic prostatitis Azithromycin is significantly more effective than ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis. Results of comparative analysis of azithromycin and ciprofloxacin for chronic prostatitis caused by C. trachomatis 2. Ciprofloxacin Azithromycin Regimen 500 mg b.i.d. for 20 days 500 mg 3 times per week for 3 weeks Bacterial eradication rate 17 of 44 patients 36 of 45 patients Clinical cure rate 15 of 44 patients 31 of 45 patients Ciprofloxacin vs Azithromycin for Gonorrhea Azithromycin is at least as effective and well tolerated as ciprofloxacin in the treatment of gonococcal infections 4. Results of single-blind comparative study of azithromycin and ciprofloxacin for gonorrhea 4. Ciprofloxacin Azithromycin Regimen single 500 mg dose single 1 g dose Clinical and microbiological cure rates after 2 weeks 92.15% (47 out of 51) 96.0% (48 out of 50) Ciprofloxacin Azithromycin Brand names • Cipro® • Cipro XR® • ProQuin XR® • Zithromax® • Z-PAK® Drug class • Antibiotic • Fluoroquinolone • Macrolide Dose formulations • Tablets • Tablets, extended release • Oral suspension • Injection • Tablets • Capsules • Powder for solution • Oral suspension FDA-approved indications • Sinusitis • Community-acquired pneumonia • Acute exacerbations of chronic bronchitis • Skin and skin structure infections • Urinary tract infections (cystitis, pyelonephritis) • Bacterial prostatitis • Infectious diarrhea • Gonococcal infections • and many other indications • Acute otitis media • Pharyngitis/tonsillitis • Urethritis and cervicitis • Chancroid "Off-label" uses • Traveler’s diarrhea • Cat scratch disease • Pelvic inflammatory disease • Pertussis • Gonococcal infections • Lyme disease Mechanism of action • Bactericidal • Ciprofloxacin inhibits bacterial DNA synthesis. Promotes breakage of double-stranded DNA. • Bacteriostatic • Azithromycin inhibits bacterial protein synthesis. Half-life • 4 hours • 40 hours Oral bioavailability • 50-85% • 37% Metabolism, Elimination • Ciprofloxacin is eliminated mainly by renal excretion. • The drug is also metabolized and partially eliminated in the bile. • Excreted billiary, mainly as unchanged drug in the feces. Urinary excretion is
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