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Author: Admin | 2025-04-28
To underestimate a patient's 24-hour DILAUDID dosage than to overestimate the 24-hour dosage and manage an adverse reaction due to overdose.In general, it is safest to start DILAUDID therapy by administering half of the usual starting dose every 3 to 6 hours for DILAUDID Oral Solution; and every 4 to 6 hours for DILAUDID Tablets. The dose of DILAUDID can be gradually adjusted until adequate pain relief and acceptable side effects have been achieved.Conversion from DILAUDID Oral Solution or DILAUDID Tablets to Extended-Release Hydromorphone HydrochlorideThe relative bioavailability of DILAUDID Oral Solution and DILAUDID Tablets compared to extended-release hydromorphone is unknown, so conversion to extended-release hydromorphone may lead to increased risk of excessive sedation and respiratory depression. Dosage Modifications in Patients with Hepatic ImpairmentInitiate treatment with one-fourth to one-half the usual DILAUDID starting dose depending on the degree of impairment. Dosage Modifications in Patients with Renal ImpairmentInitiate treatment with one-fourth to one-half the usual DILAUDID starting dose depending on the degree of impairment. Titration and Maintenance of TherapyIndividually titrate DILAUDID Oral Solution or DILAUDID Tablets to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving DILAUDID Oral Solution or DILAUDID Tablets to assess the maintenance of pain control, signs and symptoms of opioid withdrawal, and other adverse reactions, as well as to reassess for the development of addiction, abuse, or misuse. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the DILAUDID Oral Solution or DILAUDID Tablets dosage. If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after a dosage increase), consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.A supplemental dose of 5 to 15% of the total daily usage may be administered every two hours on an as-needed basis. Safe Reduction or Discontinuation of DILAUDID Oral Solution or DILAUDID TabletsDo not abruptly discontinue DILAUDID Oral Solution and DILAUDID Tablets in patients who may be physically dependent on opioids. Rapid discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide. Rapid discontinuation has also been associated with attempts to
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