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Author: Admin | 2025-04-28
Of chronic pruritus, gabapentin is recommended for chronic kidney disease-associated pruritus Restless legs syndromebyesGabapentin in the management of restless legs syndrome (RLS) has been evaluated in small controlled trials, demonstrating benefits compared with placebo. Gabapentin enacarbil is FDA-approved for the treatment of RLS Garcia-Borreguero 2002, Saletu 2010.The Social anxiety disorder, adjunct to antidepressants or monotherapy (alternative agent)cData from a limited number of patients studied in a double-blind, placebo-controlled trial suggest that gabapentin may be beneficial for the treatment of social anxiety disorder Pande 1999.Vasomotor symptoms associated with menopausebyesData from meta-analyses and an individual patient pooled analysis support the use of immediate-release gabapentin for decreasing the frequency and severity of hot flashes in postmenopausal women and breast cancer survivors Li 2016, Loprinzi 2009, Toulis 2009. Data from a randomized, double-blind, placebo-controlled study support the use of extended-release gabapentin for decreasing frequency and severity of hot flashes and associated sleep interference in postmenopausal women Pinkerton 2014.Based on the ContraindicationsHypersensitivity to gabapentin or any component of the formulation Dosage and AdministrationDosing: AdultAlcohol use disorder, moderate to severe (alternative agent) (off-label use): Immediate release: Oral: Initial: 300 mg once daily; increase dose based on response and tolerability in increments of 300 mg every 1 to 2 days up to a target dose of 600 mg 3 times daily (Brower 2008; Mason 2014; VA/DoD 2015). Note: Gabapentin is suggested by some experts as an alternative when first-line agents cannot be used (Johnson 2019; VA/DoD 2015). Gabapentin may be misused by some patients with substance use
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