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Author: Admin | 2025-04-28
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors. Effexor XR is not approved for use in pediatric patients.Contraindications:Effexor XR is contraindicated in patients: with known hypersensitivity to venlafaxine hydrochloride, desvenlafaxine succinate, or any excipients in the formulation. taking, or within 14 days of stopping, monoamine oxidase inhibitors (MAOIs) (including the MAOIs linezolid and intravenous methylene blue) because of the risk of serotonin syndrome.Warnings and Precautions:Serotonin Syndrome: Effexor XR can precipitate serotonin syndrome, a potentially life-threateningcondition. There is an increased risk when co-administered with other serotonergicagents but also when taken alone. If it occurs, discontinue Effexor XR and serotonergic agentsand initiate supportive treatment.Elevated Blood Pressure: In controlled trials, there were dose-related increases in systolic anddiastolic blood pressure, as well as cases of sustained hypertension. Control hypertensionbefore initiating treatment. Monitor blood pressure regularly during treatment.Increased Risk of Bleeding: Effexor XR may increase risk of bleeding events. Concomitantuse of aspirin, NSAIDS, other antiplatelet drugs, warfarin, and anticoagulants may increase risk.Based on data from the published observational studies, exposure to SNRIs, particularly in themonth before delivery, has been associated with a less than 2-fold increase in the risk ofpostpartum hemorrhage. Inform patients about the risk of bleeding associated with theconcomitant use of Effexor XR and NSAIDs, aspirin, or other drugs that affect coagulation.Angle-Closure Glaucoma: Angle-closure glaucoma has occurred in patients with untreatedanatomically narrow angles, treated with antidepressants.Activation of Mania/Hypomania: Screen patients for bipolar disorder. In patients with bipolardisorder, treating a depressive episode with Effexor XR may precipitate a mixed/manic episode.Discontinuation Syndrome: Abrupt discontinuation or dose reduction has been associatedwith the appearance of new symptoms. There have been postmarketing reports of seriousdiscontinuation symptoms, which can be protracted and severe. Completed suicide, suicidal thoughts, aggression, and violent behavior have been observed in patients during reduction inEffexor XR dosage, including during discontinuation. Patients should be monitored forsymptoms when discontinuing treatment with Effexor XR. A gradual reduction in the dose,rather than abrupt cessation, is recommended.Seizures: Seizures have occurred
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