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Author: Admin | 2025-04-28
Back To Search Results Editor: Contributor ProfileProfessor Istituto Nazionale Tumori - IRCCS - Fondazione Pascale, Via Mariano Semmola 80100, Napoli. Italy NapoliDisclosureMarco Cascella, MD, has no relevant financial relationships with ineligible companies.">Marco Cascella Updated: 2/28/2024 11:12:44 PM Indications Primidone is a first-generation barbiturate type antiepileptic medication developed to treat seizures, commonly for partial and generalized seizures. Primidone is not currently prescribed as a first choice to treat psychomotor, grand mal, and focal epileptic. This drug can also be utilized in the management of tremors. Since the 1980s, it has been considered a valid alternative to propranolol in treating essential tremors.[1][2] However, its use for this purpose is not recommended as first-line therapy.The drug was developed by Carrington and Yule Bogue in 1949. On March 8th, 1954, the Food and Drugs Administration (FDA) endorsed primidone for treating epilepsy.[3] Nevertheless, with the subsequent marketing of carbamazepine in 1974 and the introduction of phenytoin, zonisamide, felbamate, gabapentin, lamotrigine, and vigabatrin, the role of primidone in the treatment of epilepsies has been further reduced. Its use is relegated to treating forms resistant to other therapies. In particular, its indications include the treatment of grand mal and psychomotor epilepsy (temporal lobe epilepsy). The high efficacy of primidone in these forms has also been clinically documented in patients resistant to other therapies who have idiopathic, post-traumatic forms associated with clear signs of brain injury or with specific modifications of the EEG trace. This antiepileptic drug can also be used in the therapy of focal or Jacksonian seizures, myoclonic, and akinetic seizures.Although primidone is not a first-choice drug, its pharmacokinetic and pharmacodynamic properties must be well known to clinicians, as the drug can be particularly effective in specific clinical settings. For instance, QT-prolongation is a potentially fatal form of ventricular arrhythmia with an increased incidence among patients
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