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Author: Admin | 2025-04-28
Should be stored in tight, light-resistant containers at 15–30 and 20–25°C, respectively, while the rectal suppositories should be stored in well-closed containers at 2–8°C. Freezing of the oral solution should be avoided. Following the date of manufacture, commercially available promethazine preparations have expiration dates of 2–5 years depending on the dosage form and manufacturer.Promethazine hydrochloride injection should be stored in tight, light-resistant containers at 20–25°C with excursions of 15–30°C permitted. The injection should be discarded if the solution is discolored or contains a precipitate. Promethazine hydrochloride injection has been reported to be chemically incompatible with several drugs, especially those with an alkaline pH. However, the compatibility depends on several factors (e.g., concentration of the drugs, specific diluents used, resulting pH, temperature). Specialized references should be consulted for specific compatibility information.PreparationsExcipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) namePromethazine HydrochlorideRoutesDosage FormsStrengthsBrand NamesManufacturerOralSolution6.25 mg/5 mL*Promethazine Hydrochloride SyrupTablets12.5 mg*Phenergan (scored)WyethPromethazine Hydrochloride Tablets25 mg*Phenergan (scored)WyethPromethazine Hydrochloride Tablets50 mg*PhenerganWyethPromethazine Hydrochloride TabletsParenteralInjection25 mg/mL*Promethazine Hydrochloride InjectionInjection, for IM use only50 mg/mL*Promethazine Hydrochloride InjectionRectalSuppositories12.5 mg*PhenadozPaddockPhenerganWyethPromethazine Hydrochloride Suppositories25 mg*PhenadozPaddockPhenerganWyethPromethazine Hydrochloride Suppositories50 mg*PhenerganWyethPromethazine Hydrochloride SuppositoriesPrometheganG&W* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) namePromethazine Hydrochloride CombinationsRoutesDosage FormsStrengthsBrand NamesManufacturerOralSolution6.25 mg/5 mL with Phenylephrine Hydrochloride 5 mg/5 mL*Prometh VC SyrupActavisAHFS DI Essentials™. © Copyright 2025, Selected Revisions September 24, 2018. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.Reload page with references includedFrequently asked questionsPar promethazine with codeine vs Hi-Tech promethazine with codeine?How long does promethazine stay in your system?Medical Disclaimer
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