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Author: Admin | 2025-04-28
HomeQ & AQuestionsWhat is the half life of... Question posted by Geno1969 on 28 Nov 2015 Last updated on 15 September 2019 by JemmaCS Official Answer Medically reviewed by C. Fookes, BPharm. Last updated on Sep 16, 2019. The half-life of tramadol (immediate-release) tablets is approximately 4.9 to 7.7 hours (average 6.3 hours).However, tramadol is metabolized to an active metabolite called O-desmethyltramadol (M1) that also has pain-relieving activity. M1 has a half-life of 6 to 8.8 hours (average 7.4 hours).This means that the combined half-life of tramadol and its active metabolite is approximately 13.7 hours (range 10.9 to 16.5 hours). Both tramadol and its metabolite contribute to the overall effects of tramadol.Experts consider a medicine to be 97% cleared from someone's body after four to five half-lives. Therefore it will take approximately 68.5 hours for one dose of tramadol immediate release to be cleared from your body, although effects of tramadol will wear off much sooner.Half-life should not be confused with the duration of effect. The duration of effect of immediate-release tramadol is approximately six to eight hours following a single dose.What is half-life?The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one half (50%).The half-life of Tramadol and its metabolite is approximately 13 hours but its effects tend to last six to eight hours( immediate-release). After four to five half-lives, 97% of a drug has cleared from the body, and the drug is no longer considered to be having an effect, although, for most drugs, actual noticeable effects would have worn off well before then.This means it will take approximately 68.5 hours for one dose of Tramadol immediate release to be cleared from the body.In reality, the half-life of Tramadol varies from person to person, and even sometimes within the same person. The half-life of Tramadol can be affected by dosage or overdosage and several other factors including:Age (the half-life is prolonged in elderly people over the age of 75 years)EthnicityFormulation of Tramadol (eg controlled or immediate release)Interacting medications, especially medicines metabolized through CYP2D6, CYP3A4, or CYP2B6Kidney diseaseLiver diseasePre-existing conditionsRegular dosing.See our article Drug Half-life Explained for general information about half-lives. As stated; depends on dosing with Tramadol, but if only 1 were taken it's ~6-7 hours.Remember though, a half-life is not "how long before it's out of my system", it's "how long before HALF of what's in my system is gone".So if a 100mg pill is taken, 6-7 hours later, you'll have 50mg. Then another 6-7 hours later, you'll have 25mg, so on and so forth.See Also: Drug Half Life Explainedhttps://www.drugs.com/article/drug-half-life.html Geno; Also 1/2 life would depend on which one but as far as being able to figure out how long it well be in your system even when it is out most people have terrible withdrawals even after the medication is out of your system. like physical and mental withdrawals. good luck It depends on the strength
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