Hydrochlorothiazide mechanism of action

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Author: Admin | 2025-04-28

What is enalapril/hydrochlorothiazide used for?Enalapril/hydrochlorothiazide is commonly used to lower high blood pressure (hypertension). Lowering high blood pressure has been shown to reduce the risk of stroke, heart attack, and death.Enalapril/hydrochlorothiazide may also be used for other conditions as determined by your healthcare provider.How does enalapril/hydrochlorothiazide work (mechanism of action)?Enalapril/hydrochlorothiazide is a combination of two medicines that work by different mechanisms to lower blood pressure.Enalapril blocks the angiotensin-converting enzyme (ACE) from producing a hormone called angiotensin II. When angiotensin II binds to receptors, it causes your blood vessels to constrict, and kidneys to retain more sodium. Blocking the formation of angiotensin II helps your blood vessels relax so that blood can move through them more easily. These effects can help your heart work better, lower blood pressure, and may reduce your risk for heart attack and stroke.Hydrochlorothiazide works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. It also appears to allow blood to flow more freely (less resistance to flow), which may help with lowering blood pressure.How is enalapril/hydrochlorothiazide supplied (dosage forms)?Brands and other namesVasereticDosage forms and strengths5 mg/12.5 mg oral tablets10 mg/25 mg oral tabletsHow should I store enalapril/hydrochlorothiazide?Enalapril/hydrochlorothiazide should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting it.

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