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Author: Admin | 2025-04-28
Because children 2–3 years of age also are at increased risk of overdosage and toxicity, some manufacturers of oral OTC cough and cold preparations agreed to voluntarily revise the product labeling to state that such preparations should not be used in children FDA recommends that parents and caregivers adhere to dosage instructions and warnings on the product labeling that accompanies the preparation and consult a clinician about any concerns. Geriatric UseIncreased risk for serious adverse cardiovascular, GI, and renal effects. Fatal adverse GI effects reported more frequently in geriatric patients than younger adults. If anticipated benefits outweigh potential risks, initiate at lower end of dosing range and monitor for adverse effects.Experience in those ≥65 years of age insufficient to determine whether they respond differently to IV ibuprofen than do younger adults. Select dosage with caution, starting at the low end of the dosage range, because of age-related decreases in hepatic, renal, and/or cardiac function and potential for concomitant disease and drug therapy.Renal ImpairmentMay hasten progression of renal dysfunction in patients with preexisting renal disease. Monitor patients with preexisting renal disease for worsening renal function.Not evaluated in patients with severe renal impairment. Avoid use in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function; close monitoring of renal function advised if used. Ibuprofen lysine contraindicated in neonates with substantially impaired renal function.Common Adverse EffectsWith oral ibuprofen therapy, dizziness, epigastric pain, heartburn, nausea, rash. With IV ibuprofen therapy, nausea, flatulence, vomiting, headache, hemorrhage, and dizziness in adults; infusion site pain, vomiting, nausea, anemia, and headache in pediatric patients.With IV ibuprofen lysine therapy, sepsis, anemia, bleeding, apnea, adverse GI effects, renal impairment, respiratory tract infection, dermatologic effects, hypoglycemia, hypocalcemia, respiratory failure.Drug InteractionsNo evidence of enzyme induction.Specific DrugsDrugInteractionCommentsACE inhibitorsReduced BP response to ACE inhibitor Possible deterioration of renal function, including acute renal failure, in geriatric patients and patients with volume depletion or renal impairmentMonitor BP Ensure adequate hydration; assess renal function when initiating concomitant therapy and periodically thereafterMonitor geriatric patients and patients with volume depletion or renal impairment for worsening renal functionβ-Adrenergic blocking agentsReduced BP response to
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