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Author: Admin | 2025-04-28
CYP2D6: Potential pharmacokinetic interaction (increased plasma substrate concentrations). Dosage reduction of the CYP2D6 substrate may be necessary, particularly for drugs with a narrow therapeutic index. Prodrugs dependent on CYP2D6 for activation: Possible reduced clinical efficacy of the prodrug. An increase in dosage of the prodrug may be necessary. Smoking CessationSmoking may induce enzymes and increase metabolism of some drugs. Therefore, cessation of smoking (with or without adjunctive use of bupropion) may result in decreased enzyme induction and altered metabolism of some drugs (e.g., theophylline, warfarin, insulin); consider dosage adjustment.Specific DrugsDrugInteractionCommentsAlcoholPossible neuropsychiatric effects or reduced alcohol tolerance Minimize or avoid alcohol consumption AmantadinePotential increased incidence of adverse CNS effects (e.g., restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, dizziness) Use concomitantly with caution Antiarrhythmic agents, class 1C (e.g., flecainide, propafenone)Possible decreased metabolism of antiarrhythmic agent Use with caution; consider dosage reduction of antiarrhythmic agent AntidepressantsPossible lowering of seizure threshold; increased risk of seizures Use with extreme caution; initiate therapy with lower dosages of bupropion and increase gradually Antidepressants, SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline)Possible decreased metabolism of SSRI Possible decreased metabolism of bupropion Use with caution; consider dosage reduction of SSRI Antidepressants, tricyclic (TCAs) (e.g., desipramine, imipramine, nortriptyline)Possible decreased TCA metabolism Use with caution; consider dosage reduction of TCA Antipsychotic agents (e.g., haloperidol, risperidone, thioridazine)Possible lowering of seizure threshold; increased risk of seizures Possible decreased metabolism of antipsychotic Use with extreme caution; initiate therapy with lower dosages of bupropion and increase gradually Use with caution; consider dosage reduction of antipsychotic agent β-Adrenergic blocking agents (e.g., metoprolol)Possible decreased metabolism of β-blocker Use with caution; consider dosage reduction of β-blocker BenzodiazepinesIncreased risk of seizures with excessive use or abrupt discontinuance Use with extreme caution; initiate therapy with lower dosages of bupropion and increase gradually CarbamazepinePossible increased metabolism of bupropion Increase in bupropion dosage may
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