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Author: Admin | 2025-04-28
Key PointsPaxlovid (nirmatrelvir and ritonavir) and Lagevrio (molnupiravir) are two oral treatment options for mild-to-moderate coronavirus disease 2019 (COVID-19) in people who are at high risk for severe COVID-19 disease.Both Paxlovid and Lagevrio are taken by mouth twice a day for 5 days, and should be started within 5 days of COVID-19 symptoms beginning.Paxlovid can be used in adults and children ages 12 years and older who weigh at least 40 kg, while Lagevrio can only be used in adults.CDC guidelines recommend Paxlovid as a first-choice treatment option, while Lagevrio should be taken by people who cannot take alternative COVID-19 treatment options.Paxlovid (nirmatrelvir and ritonavir) and Lagevrio (molnupiravir) are oral antiviral medications used to treat certain people with mild-to-moderate COVID-19. Both medications aim to reduce the severity of illness and prevent hospitalization. However, there are some key differences between them.What is Paxlovid?Paxlovid is an oral treatment option for mild-to-moderate COVID-19. It contains two medications, nirmatrelvir and ritonavir, that should be taken together at the same time. It is FDA approved in adults who are at high risk for severe COVID-19. Children 12 years and older who weigh at least 40 kg (88 lbs) may also take Paxlovid under the FDA’s Emergency Use Authorization.Paxlovid is not approved for use as pre-exposure prophylaxis or post-exposure prophylaxis to prevent COVID-19, nor is it approved to treat long COVID.What is Lagevrio?Lagevrio, which contains the antiviral molnupiravir, is also an oral treatment option for mild-to-moderate COVID-19. It is authorized under the FDA’s Emergency Use Authorization for adults who are at high risk for severe COVID-19, and who cannot take alternative treatment options.Lagevrio is only authorized for use in adults. It is not authorized for people younger than 18 years old. Similar to Paxlovid, Lagevrio should not be used for pre-exposure or post-exposure prophylaxis for the prevention of COVID-19.How do Paxlovid and Lagevrio work?Paxlovid and Lagevrio are both antiviral medications, but they work differently to treat COVID-19.Paxlovid contains two medications: nirmatrelvir and ritonavir. These medications work together to fight COVID-19.Nirmatrelvir is a protease inhibitor. It blocks a protein in SARS-CoV-2 and prevents it from processing proteins that are required for the virus to multiply and spread in your body.Ritonavir is also a protease inhibitor, but doesn’t directly treat COVID-19. Instead, it blocks enzymes in your liver that break down nirmatrelvir. This keeps it around in your blood longer.Lagevrio contains an antiviral medication called molnupiravir. It works
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