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Author: Admin | 2025-04-28
Data indicates that escitalopram is the most cost-effective antidepressant compared with other SSRIs31. The fastest SSRI Escitalopram has a rapid onset of antidepressant effect and is a good choice when rapid antidepressant response is desirable. Fluoxetine has the slowest onset of antidepressant action. The most sedative SSRI Fluvoxamine and paroxetine are the most sedating of the SSRIs. The most activating SSRIFluoxetine and sertraline are more activating and preferred in depressed patients with apathy, lack of energy, or hypersomnia. And they are least preferred in patients with anxiety and insomnia. The lowest risk for drug interactions Sertraline and citalopram have the lowest risk of enzyme inhibition making them the SSRIs of choice in patients at risk for drug interactions. The best SSRI for anxiety Escitalopram has potent anxiolytic-like effects32. The best tolerated SSRI Escitalopram and sertraline appear to be the best tolerated antidepressants. For patients with poor compliance with medication or those likely to miss doses or interrupt treatment - fluoxetine is the best SSRI. References Celexa Prescribing Information Forest Pharmaceuticals, Inc. Lexapro Prescribing Information PDF Paxil Prescribing Information PDF Prozac Prescribing Information Eli Lilly and Company Zoloft Prescribing Information Pfizer Inc. 1. Side-effect profile of fluoxetine in comparison with other SSRIs, tricyclic and newer antidepressants: a meta-analysis of clinical trial data. Pharmacopsychiatry. 2005 Mar;38(2):69-77 MedLine 2. Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis. J Psychiatry Neurosci. 2006 Mar;31(2):122-31. MedLine 3. Kroenke K, West SL, Swindle R, Gilsenan A, Eckert GJ, Dolor R, Stang P, Zhou XH, Hays R, Weinberger M. Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial. JAMA. 2001 Dec 19;286(23):2947-55 4. Escitalopram is more effective than citalopram for the treatment of severe major depressive disorder Encephale. 2004 Mar-Apr;30(2):158-66. 5. Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression. J Affect Disord. 2000 Aug;59(2):119-26. 6. Labbate LA. Sex and serotonin reuptake inhibitor antidepressants. Psychiatr Ann. 1999;29:571–9. 7. Meijer WE, Heerdink ER, van Eijk JT, Leufkens HG. Adverse events in users of sertraline: results from
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