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Author: Admin | 2025-04-28
What is lisinopril/hydrochlorothiazide used for?Lisinopril/hydrochlorothiazide is commonly used to lower high blood pressure (hypertension). Lowering high blood pressure has been shown to reduce the risk of stroke, heart attack, and death.Lisinopril/hydrochlorothiazide may also be used for other conditions as determined by your healthcare provider.How does lisinopril/hydrochlorothiazide work (mechanism of action)?Lisinopril/hydrochlorothiazide is a combination of two medicines that work by different mechanisms to lower blood pressure.Lisinopril blocks the angiotensin-converting enzyme (ACE) from producing a hormone called angiotensin II. When angiotensin II binds to receptors, it causes your blood vessels to constrict, and kidneys to retain more sodium. Blocking the formation of angiotensin II helps your blood vessels relax so that blood can move through them more easily. These effects can help your heart work better, lower blood pressure, and may reduce your risk for heart attack and stroke.Hydrochlorothiazide works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. It also appears to allow blood to flow more freely (less resistance to flow), which may help with lowering blood pressure.How is lisinopril/hydrochlorothiazide supplied (dosage forms)?Brands and other namesZestoreticDosage forms and strengths10 mg/12.5 mg oral tablets20 mg/25 mg oral tablets20 mg/25 mg oral tabletsHow should I store lisinopril/hydrochlorothiazide?Lisinopril/hydrochlorothiazide should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting it. Store in a cool, dry place. Protect from light. Keep tightly closed. Side Effects What are the most common side effects of lisinopril/hydrochlorothiazide?The most common side effects of lisinopril/hydrochlorothiazide are listed below. Tell your healthcare provider if you have any of these side effects that bother you.Dizziness or feeling lightheaded, especially upon standingHeadacheCoughTiredness, fatigue, or weaknessDiarrhea and/or stomach painNausea/vomitingInfection of the nose or throat, sore throat, or common cold symptomsMuscle crampsNumbness, tingling, or burning in your arms, feet, or faceLow blood pressureMuscle spasmsRashProblems getting or keeping an erectionAn increase in how much you peeThere may be other side effects of lisinopril/hydrochlorothiazide that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects
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