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Author: Admin | 2025-04-28
Is more effective for anxiety?Trials that directly compared Ativan and Xanax for the treatment of anxiety have reported no significant differences in their effect, and few differences in their side effects, although mental confusion may be less with Xanax.5,6Which drug is more addictive?Both Ativan and Xanax should only be used short-term due to risk of addiction and dependence. Generally speaking, benzodiazepines with a shorter half life (such as Ativan and Xanax) are harder to stop than those with a longer half life (such as diazepam). Both Ativan and Xanax readily enter brain tissue which reinforces drug taking and is generally associated with more severe withdrawal symptoms. Therefore, Ativan and Xanax are both at high risk of abuse. Research directly comparing Ativan with Xanax is not available; however, many experts have particularly advised that Xanax be used with caution as it has been associated with particularly severe withdrawal symptoms. ReferencesAtivan (lorazepam injection) [Package Insert] Revised 11/2011 West-ward Pharmaceutical Corp. https://www.drugs.com/pro/ativan.html Accessed 03/2016Xanax (alprazolam) [Package Insert] Revised 03/2015 Pharmacia and Upjohn Company https://www.drugs.com/pro/xanax.html Accessed 03/2016Benzodiazepine equivalency table Revised April 2007 http://www.benzo.org.uk/bzequiv.htm Accessed 03/2016Bernardi F, Fossi L, Faravelli C, et al. Alprazolam versus lorazepam in the treatment of anxiety: controlled clinical study. Riv Patol Nerv Ment. 1984 Jan-Feb;105(1):1-13.Botte L, Bienfait J, Dethier J et al. Clinical comparison between alprazolam and lorazepam. A polycentric study in double blind. Acta Psychiatr Belg. 1981 Nov-Dec;81(6):595-608.Greenblatt DJ, Harmatz JS, Dorsey C, Shader RI. Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. Clin Pharmacol Ther.
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