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Author: Admin | 2025-04-28
In 30 to 60 minutes after the initial dose if neededChronic pain (moderate to severe):Buccal film: Note: Buprenorphine buccal film doses of 600, 750, and 900 mcg are only for use following titration from lower doses (maximum dose: 900 mcg every 12 hours).Opioid-naive patients and opioid-non-tolerant patients: Initial: 75 mcg once daily or, if tolerated, every 12 hours for at least 4 days, then increase to 150 mcg every 12 hours.Opioid-experienced patients (conversion from other opioids to buprenorphine): Discontinue all other around-the-clock opioids when buprenorphine is initiated. Taper patient's current opioid to no more than 30 mg oral morphine sulfate equivalents daily before initiating buprenorphine. Following analgesic taper, base the initial buprenorphine dose on the patient's daily opioid dose prior to taper. Patients may require additional short-acting analgesics during the taper period.Patients who were receiving daily dose of Patients who were receiving daily dose of 30 to 89 mg of oral morphine equivalents: Initial: 150 mcg every 12 hoursPatients who were receiving daily dose of 90 to 160 mg of oral morphine equivalents: Initial: 300 mcg every 12 hoursPatients who were receiving daily dose of >160 mg of oral morphine equivalents: Buprenorphine buccal film may not provide adequate analgesia; consider the use of an alternate analgesic.Conversion from methadone: Close monitoring is required when converting methadone to another opioid. Ratio between methadone and other opioid agonists varies widely according to previous dose exposure. Methadone has a long half-life and can accumulate in the plasma.Dose titration (opioid-naive or opioid-experienced patients): Individually titrate
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