Comment
Author: Admin | 2025-04-28
With strong CYP2C8 inhibitors (eg, gemfibrozil): Maximum recommended dose: 15 mg once daily.Dosing: GeriatricRefer to adult dosing.AdministrationOral: May be administered without regard to meals Dietary ConsiderationsIndividualized medical nutrition therapy (MNT) is an integral part of therapy StorageStore at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light, moisture, and humidity. Pioglitazone Images pioglitazone 15 mg (base) pioglitazone 30 mg (base) pioglitazone 45 mg (base) pioglitazone 15 mg (base) pioglitazone 30 mg (base) pioglitazone 45 mg (base) Drug InteractionsAlpha-Lipoic Acid: May enhance the hypoglycemic effect of Antidiabetic Agents. Monitor therapyAndrogens: May enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Exceptions: Danazol. Monitor therapyCYP2C8 Inducers (Moderate): May decrease the serum concentration of Pioglitazone. Monitor therapyCYP2C8 Inhibitors (Moderate): May increase the serum concentration of Pioglitazone. Monitor therapyCYP2C8 Inhibitors (Strong): May increase the serum concentration of Pioglitazone. Management: Limit the pioglitazone dose to 15 mg daily and monitor for increased pioglitazone toxicities (eg, hypoglycemia) when used in combination with strong CYP2C8 inhibitors. Consider therapy modificationDirect Acting Antiviral Agents (HCV): May enhance the hypoglycemic effect of Antidiabetic Agents. Monitor therapyGuanethidine: May enhance the hypoglycemic effect of Antidiabetic Agents. Monitor therapyHyperglycemia-Associated Agents: May diminish the therapeutic effect of Antidiabetic Agents. Monitor therapyHypoglycemia-Associated Agents: Antidiabetic Agents may enhance the hypoglycemic effect of Hypoglycemia-Associated Agents. Monitor therapyInsulins: Pioglitazone may enhance the adverse/toxic effect of Insulins. Specifically, the risk for hypoglycemia, fluid retention, and heart failure may be increased with this combination. Management: If insulin is combined with pioglitazone, dose reductions should be
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