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Author: Admin | 2025-04-28
Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.Applies to the following strengths: 10 mg-100 mg; 25 mg-100 mg; 25 mg-250 mg; 50 mg-200 mg; 4.63 mg-20 mg/mL; 23.75 mg-95 mg; 36.25 mg-145 mg; 48.75 mg-195 mg; 61.25 mg-245 mg; 35 mg-140 mg; 52.5 mg-210 mg; 70 mg-280 mg; 87.5 mg-350 mgUsual Adult Dose for:Parkinson's DiseaseAdditional dosage information:Renal Dose AdjustmentsLiver Dose AdjustmentsDose AdjustmentsPrecautionsDialysisOther CommentsUsual Adult Dose for Parkinson's DiseaseOptimum dosage is determined by careful individual titration: All doses expressed as CARBIDOPA-LEVODOPAImmediate-release including Oral disintegrating tablets:Initial dose: 25 mg-100 mg orally three times a day or 10 mg-100 mg orally 3 or 4 times a dayIncrease by 1 tablet every day or every other day as needed until a dose of 8 tablets is reached; may use a combination of tablets from both ratios (1:4 or 1:10) to provide the optimum dose.Conversion from LEVODOPA:Levodopa should be discontinued at least 12 hours before starting carbidopa-levodopa; initiate with approximately 25% of the previous levodopa dose.Suggested dose for patients receiving less than levodopa 1500 mg per day: 25 mg-100 mg orally 3 or 4 times a day.Suggested dose for patients receiving more than levodopa 1500 mg per day: 25 mg-250 mg orally 3 or 4 times a day.Sustained-Release Tablets (SINEMET CR):Initial dose (levodopa-naive): 50 mg-200 mg orally twice a day; initial dosage should be given at intervals of more than 6 hoursDose and dosing interval may be increased or decreased at intervals of at least 3 days based on therapeutic responseDose range: Most
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